Inflammatory phase The body’s first response to an injury is the inflammatory phase. The blood vessels in the wound bed contract and a blood clot is formed. Once the bleeding has stopped the blood vessels dilate again to let mostly white blood cells, and other essential cells pass through to reach the wound. There they start to repair the damaged tissue. This stage is where you can observe the typical signs of the inflammatory phase: a reddened skin (erythema), heat, edema and pain. A scab forms on top of the wound within the first few days. |
Proliferation phase The proliferation phase follows shortly after the inflammatory phase. This is where the wound is repaired with so called granulating tissue which mostly consists of collagen. Fibroblasts are the active cells that produce the flexible and tough collagen fibers to provide strength and structure within the granulating tissue. Blood vessels also form in this newly built tissue and bring oxygen and nutrients to the cells in the reconstructive work and remove waste products from the wound. At this stage, the epidermis begins to close on top of the wound. In addition to this, the edges of the wound are gradually being pulled together and the wound becomes smaller. |
Maturation phase Several weeks after the proliferation phase the maturation phase begins. The longest and final phase of the wound healing process can take up to two years to conclude. The capillaries (blood vessels), which are no longer needed, begin to thin out. The collagen of the proliferation phase is replaced by a much stronger type of collagen and the wound continues to contract. At the end of the maturation phase the wound is permanently sealed with collagen scar tissue which has little of the cell activity present than regular skin. |
Inflammatory phase The body’s first response to an injury is the inflammatory phase. The blood vessels in the wound bed contract and a blood clot is formed. Once the bleeding has stopped the blood vessels dilate again to let mostly white blood cells, and other essential cells pass through to reach the wound. There they start to repair the damaged tissue. This stage is where you can observe the typical signs of the inflammatory phase: a reddened skin (erythema), heat, edema and pain. A scab forms on top of the wound within the first few days. |